PTDSS2

Across TCGA patient cohorts, PTDSS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,165 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PTDSS2-associated GO terms across cancer lineages are tRNA thio-modification, Obsolete positive regulation of histone deacetylation, and Positive regulation of T cell mediated immune response to tumor cell. Each is linked with PTDSS2 in more than 21 cancer types. Because this analysis shows association rather than direction, both PTDSS2-to-partner and partner-to-PTDSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA thio-modification grouped by PTDSS2-low versus PTDSS2-high in READ.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTDSS2→partner) and Y-score (partner→PTDSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	tRNA thio-modification →	+0.061	+0.616	<.001	<.001	3	22
SCLC	Obsolete positive regulation of histone deacetylation →	+0.081	+0.502	.004	<.001	3	22
LAML	Positive regulation of T cell mediated immune response to tumor cell →	-0.046	-0.443	.004	<.001	2	20
DLBC	Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation →	-0.082	-0.475	<.001	<.001	3	18
DLBC	[4Fe-4S] cluster assembly →	+0.082	+0.481	<.001	.001	3	18
THYM	Regulation of T cell mediated immune response to tumor cell →	-0.054	-0.561	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,165 associations by consensus.

tRNA thio-modification by PTDSS2 expression — READ

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