PTDSS2

Across TCGA pan-cancer cohorts, PTDSS2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PTDSS2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PTDSS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTDSS2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, LIHC, and STAD are the cancer types where PTDSS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTDSS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.067	<.001	11	view →
LIHC	Female	II,III,IV	+1.395	<.001	9	view →
STAD	Male	II,III,IV	+1.147	<.001	6	view →
THCA	Male	IV	−0.809	<.001	6	view →
CHOL	All	All	+2.108	<.001	5	view →
KICH	Female	All	+0.560	.008	4	view →
ESCA	All	All	+0.567	.002	2	view →
PAAD	Female	All	+0.339	<.001	2	view →
HNSC	All	All	+0.243	.016	2	view →
PRAD	All	All	+0.173	.025	2	view →
KIRC	Female	IV	+0.641	.032	1	view →
READ	All	All	+0.497	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PTDSS2–COAD

Open the COAD breakdown →