PTDSS2

Across TCGA patient cohorts, PTDSS2 mutation is significantly associated with the RNA expression of many other genes, with 740 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTDSS2-associated genes across cancer lineages are RNU6-742P, MIR4727, and RNA5SP452. Each is linked with PTDSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTDSS2-to-partner and partner-to-PTDSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-742P grouped by PTDSS2-low versus PTDSS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTDSS2→partner) and Y-score (partner→PTDSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-742P →	+0.830	+3.636	<.001	.006	3	2
COAD	MIR4727 →	+0.340	+4.392	.002	.006	3	2
CESC	RNA5SP452 →	+0.314	+4.234	.005	.003	3	2
UCEC	RNA5SP422 →	+0.808	+2.308	<.001	.002	3	2
UCEC	RNA5SP415 →	+0.641	+3.126	<.001	<.001	3	2
BRCA	MIR3118-3 →	+0.371	+7.471	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 740 associations by consensus.

RNU6-742P by PTDSS2 expression — COAD

Explore this box plot interactively →