PTDSS2

Across TCGA patient cohorts, PTDSS2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTDSS2-associated genes across cancer lineages are AMPK_pT172, ASNS, and C-Raf. Each is linked with PTDSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTDSS2-to-partner and partner-to-PTDSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_pT172 grouped by PTDSS2-low versus PTDSS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTDSS2→partner) and Y-score (partner→PTDSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AMPK_pT172 →	+0.468	+2.013	.011	.018	3	2
UCEC	ASNS →	+0.448	+2.999	.005	.035	3	2
UCEC	C-Raf →	+0.195	+2.000	.002	.032	3	2
UCEC	A-Raf_pS299 →	-0.157	-2.459	.003	.019	3	1
UCEC	Ku80 →	+0.306	+2.469	.004	.010	3	1
UCEC	MEK1 →	+0.425	+3.459	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

AMPK_pT172 by PTDSS2 expression — UCEC

Explore this box plot interactively →