PTDSS2

Across TCGA cell cohorts, PTDSS2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTDSS2-associated genes across cancer lineages are MS4A5, OC90, and MAGEB4. Each is linked with PTDSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTDSS2-to-partner and partner-to-PTDSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A5 grouped by PTDSS2-low versus PTDSS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTDSS2→partner) and Y-score (partner→PTDSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MS4A5 →	+0.082	+5.969	<.001	.001	3	1
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MS4A5 by PTDSS2 expression — BLOOD_Leukemia

Explore this box plot interactively →