PTCHD4

Across TCGA patient cohorts, PTCHD4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTCHD4-associated genes across cancer lineages are XBP1, Cyclin-B1, and Di-Ras3. Each is linked with PTCHD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTCHD4-to-partner and partner-to-PTCHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by PTCHD4-low versus PTCHD4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCHD4→partner) and Y-score (partner→PTCHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	XBP1 →	-0.297	-3.169	.026	.019	3	3
UCEC	Cyclin-B1 →	+0.520	+2.222	.002	.009	3	3
UCEC	Di-Ras3 →	-0.146	-2.893	.001	.001	3	3
SKCM	NDRG1_pT346 →	-0.724	-3.169	.043	.019	3	2
UCEC	ACVRL1 →	-0.085	-1.342	.042	.034	3	2
UCEC	JNK_pT183_Y185 →	-0.150	-1.662	.003	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

XBP1 by PTCHD4 expression — SKCM

Explore this box plot interactively →