PTCHD4

Across TCGA cell cohorts, PTCHD4 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTCHD4-associated genes across cancer lineages are MYL2, SCGB1C1, and SLC22A2. Each is linked with PTCHD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTCHD4-to-partner and partner-to-PTCHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYL2 grouped by PTCHD4-low versus PTCHD4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCHD4→partner) and Y-score (partner→PTCHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MYL2 →	+0.165	+3.684	.001	.001	3	2
BLOOD_Lymphoma	SCGB1C1 →	+0.072	+3.714	.009	.006	3	1
LUNG_SCLC	SLC22A2 →	+0.026	+3.256	.003	.005	3	1
LUNG_SCLC	IL1RL1 →	+0.054	+4.209	<.001	.002	3	1
LUNG_SCLC	LCE3D →	+0.065	+3.232	<.001	.008	3	1
LUNG_SCLC	GKN1 →	+0.143	+3.459	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

MYL2 by PTCHD4 expression — LUNG_SCLC

Explore this box plot interactively →