PTCHD3

Across TCGA patient cohorts, PTCHD3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTCHD3-associated genes across cancer lineages are c-Kit, ERK2, and MEK1. Each is linked with PTCHD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTCHD3-to-partner and partner-to-PTCHD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by PTCHD3-low versus PTCHD3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTCHD3→partner) and Y-score (partner→PTCHD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	c-Kit →	+0.886	+3.000	.001	.034	3	2
UCEC	ERK2 →	+0.149	+1.662	.010	.010	3	2
UCEC	MEK1 →	+0.361	+2.502	.001	.001	3	2
UCEC	Notch1 →	+0.152	+2.672	<.001	<.001	3	2
UCEC	PKC-b-II_pS660 →	-0.175	-1.125	.036	.033	3	2
UCEC	BRCA2 →	-0.106	-1.754	.007	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

c-Kit by PTCHD3 expression — COAD

Explore this box plot interactively →