PTCHD1-AS

Across TCGA pan-cancer cohorts, PTCHD1-AS RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PTCHD1-AS’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where PTCHD1-AS RNA is repressed in tumor relative to normal tissue. In most cancer types PTCHD1-AS is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and COAD are the cancer types where PTCHD1-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTCHD1-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.283	<.001	8	view →
KICH	All	II,III,IV	−0.144	<.001	7	view →
COAD	All	II,III,IV	−0.098	<.001	7	view →
KIRP	All	All	+0.217	<.001	6	view →
BLCA	Male	III,IV	−0.624	.012	4	view →
STAD	All	All	−0.278	.002	3	view →
THCA	All	II,III,IV	−0.270	.005	3	view →
PRAD	All	All	−0.215	<.001	2	view →
READ	All	III,IV	−0.075	.037	2	view →
LUAD	Male	III,IV	−0.133	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PTCHD1-AS–BRCA

Open the BRCA breakdown →