PTBP3

Across TCGA patient cohorts, PTBP3 mutation is significantly associated with the RNA expression of many other genes, with 4,591 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTBP3-associated genes across cancer lineages are RN7SL261P, TBR1, and EI24. Each is linked with PTBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTBP3-to-partner and partner-to-PTBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL261P grouped by PTBP3-low versus PTBP3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP3→partner) and Y-score (partner→PTBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL261P →	+0.178	+3.811	<.001	.004	3	2
COAD	TBR1 →	+0.353	+3.932	<.001	.004	3	2
UCEC	EI24 →	+0.549	+2.485	<.001	<.001	3	2
UCEC	KCTD14 →	+0.677	+1.676	.003	.001	3	2
UCEC	CLPB →	+0.466	+2.234	<.001	<.001	3	2
UCEC	RCHY1 →	+0.433	+3.108	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,591 associations by consensus.

RN7SL261P by PTBP3 expression — BRCA

Explore this box plot interactively →