PTBP3

Across TCGA cell cohorts, PTBP3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PTBP3-associated genes across cancer lineages are R3HDML, BANF2, and DMRTB1. Each is linked with PTBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTBP3-to-partner and partner-to-PTBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by PTBP3-low versus PTBP3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP3→partner) and Y-score (partner→PTBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	R3HDML →	+0.007	+5.794	<.001	<.001	3	1
BLOOD_Lymphoma	BANF2 →	+0.035	+4.643	.003	.005	3	1
BLOOD_Lymphoma	DMRTB1 →	+0.026	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	DPPA2 →	+0.339	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	CSN3 →	+0.183	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	OR2AK2 →	+0.037	+4.191	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

R3HDML by PTBP3 expression — BLOOD_Lymphoma

Explore this box plot interactively →