PTBP2

Across TCGA patient cohorts, PTBP2 mutation is significantly associated with the RNA expression of many other genes, with 2,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTBP2-associated genes across cancer lineages are KRT18P45, LINC02337, and NOCT. Each is linked with PTBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTBP2-to-partner and partner-to-PTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT18P45 grouped by PTBP2-low versus PTBP2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP2→partner) and Y-score (partner→PTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	KRT18P45 →	+0.053	+3.944	<.001	.007	3	3
BLCA	LINC02337 →	+0.455	+5.289	<.001	.003	3	3
UCEC	NOCT →	+0.472	+2.510	.001	.001	3	3
COAD	RPS6P20 →	+0.296	+3.522	<.001	.001	3	3
LUAD	GAGE13 →	+0.076	+4.523	<.001	.004	3	3
UCEC	AAGAB →	+0.524	+3.108	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,586 associations by consensus.

KRT18P45 by PTBP2 expression — CESC

Explore this box plot interactively →