PTBP1

Across TCGA patient cohorts, PTBP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,256 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PTBP1-associated proteins across cancer lineages are SPC25, POLD2, and POLR1E. Each is linked with PTBP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PTBP1-to-partner and partner-to-PTBP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTBP1 versus SPC25 in GBM, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP1→partner) and Y-score (partner→PTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPC25 →	+0.819	+0.394	<.001	<.001	3	7
LSCC	POLD2 →	+0.399	+0.464	<.001	<.001	3	6
GBM	POLR1E →	+0.377	+0.393	<.001	<.001	3	6
LUAD	PURA →	-0.359	-0.417	<.001	<.001	3	6
LSCC	UTP4 →	+0.435	+0.452	<.001	<.001	3	6
GBM	NCAPD2 →	+0.794	+0.488	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,256 associations by consensus.

PTBP1 vs SPC25 — GBM

Explore this scatter interactively →