PTBP1

Across TCGA pan-cancer cohorts, PTBP1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PTBP1 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PTBP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTBP1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

ACC, MESO, and KICH are the cancer types where PTBP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.385	0.767	<.001	103	view →
MESO	OS	Quartile	All	0.336	0.671	<.001	94	view →
KICH	DFS	Quartile	III,IV	0.179	1.000	.003	74	view →
LUAD	DFS	Median	All	0.734	0.843	<.001	64	view →
KIRP	DFS	Tertile	All	0.758	0.926	<.001	63	view →
LIHC	DFS	Quartile	All	0.380	0.590	<.001	59	view →
LGG	DFS	Median	All	0.650	0.828	<.001	54	view →
KIRC	DFS	Median	All	0.763	0.494	<.001	49	view →
UVM	DFS	Tertile	All	0.407	0.763	.002	37	view →
OV	DFS	Quartile	All	0.462	0.344	.009	32	view →
SARC	OS	Tertile	All	0.422	0.814	<.001	31	view →
SKCM	OS	Median	All	0.284	0.405	.002	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PTBP1–ACC (DFS)

Open the ACC breakdown →