PTBP1

Across TCGA patient cohorts, PTBP1 mutation is significantly associated with the RNA expression of many other genes, with 4,428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTBP1-associated genes across cancer lineages are RNU6-739P, DHDDS, and NANOGP3. Each is linked with PTBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTBP1-to-partner and partner-to-PTBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-739P grouped by PTBP1-low versus PTBP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP1→partner) and Y-score (partner→PTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-739P →	+0.106	+4.049	<.001	.007	3	3
UCEC	DHDDS →	+0.494	+3.180	<.001	<.001	3	3
LIHC	NANOGP3 →	+0.220	+4.690	<.001	.003	3	2
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
SKCM	RN7SL162P →	+0.153	+3.178	<.001	<.001	3	2
CESC	XAGE1A →	+0.019	+4.516	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,428 associations by consensus.

RNU6-739P by PTBP1 expression — SKCM

Explore this box plot interactively →