PTBP1

Across TCGA patient cohorts, PTBP1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTBP1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and Caspase-7-cleavedD198. Each is linked with PTBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTBP1-to-partner and partner-to-PTBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PTBP1-low versus PTBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP1→partner) and Y-score (partner→PTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.190	-1.662	.032	.011	3	2
UCEC	eIF4E →	+0.248	+2.874	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.679	+2.392	.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.554	+3.321	.005	.009	3	2
UCEC	A-Raf_pS299 →	-0.129	-2.115	.002	.017	3	1
UCEC	GATA6 →	-0.161	-3.307	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR_pY1068 by PTBP1 expression — UCEC

Explore this box plot interactively →