PTBP1

Across TCGA cell cohorts, PTBP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,465 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PTBP1-associated GO terms across cancer lineages are Positive regulation of mitotic cytokinesis, Mitotic chromosome condensation, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with PTBP1 in more than 18 cancer types. Because this analysis shows association rather than direction, both PTBP1-to-partner and partner-to-PTBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cytokinesis grouped by PTBP1-low versus PTBP1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP1→partner) and Y-score (partner→PTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cytokinesis →	+0.177	+0.815	<.001	.006	3	19
UPPER_AERODIGESTIVE_TRACT	Mitotic chromosome condensation →	+0.166	+0.963	.001	.002	3	18
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.171	+0.849	.003	<.001	3	18
PANCREAS	Chromosome condensation →	+0.162	+0.961	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Mitotic spindle elongation →	+0.290	+0.764	<.001	.006	2	19
LUNG_NSCLC_LUSC	Mitotic spindle midzone assembly →	+0.290	+0.764	<.001	.006	2	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,465 associations by consensus.

Positive regulation of mitotic cytokinesis by PTBP1 expression — UPPER_AERODIGESTIVE_TRACT

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