PTBP1

Across TCGA cell cohorts, PTBP1 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PTBP1-associated genes across cancer lineages are KRT77, SPRR1A, and DEFB134. Each is linked with PTBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTBP1-to-partner and partner-to-PTBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT77 grouped by PTBP1-low versus PTBP1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP1→partner) and Y-score (partner→PTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRT77 →	+0.089	+4.095	.002	.009	3	1
BLOOD_Leukemia	SPRR1A →	+0.217	+4.786	<.001	<.001	3	1
BLOOD_Leukemia	DEFB134 →	+0.013	+4.384	<.001	.006	3	1
BLOOD_Leukemia	SMIM32 →	+0.026	+4.169	<.001	.008	3	1
BLOOD_Lymphoma	PPP1R2C →	+0.456	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	TAS2R7 →	+0.042	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

KRT77 by PTBP1 expression — SKIN

Explore this box plot interactively →