PTBP1

Across TCGA cell cohorts, PTBP1 mutation is significantly associated with the mutation status of many other genes, with 3,898 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTBP1-associated genes across cancer lineages are RPTOR, ASAP2, and HIVEP1. Each is linked with PTBP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTBP1-to-partner and partner-to-PTBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPTOR grouped by PTBP1-low versus PTBP1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTBP1→partner) and Y-score (partner→PTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPTOR →	+4.187	+5.000	.008	.008	1	4
LUNG_NSCLC_LUAD	ASAP2 →	+5.772	+5.772	.002	.002	1	4
BLOOD_Lymphoma	HIVEP1 →	+3.662	+5.169	<.001	<.001	1	4
BLOOD_Leukemia	EHMT1 →	+3.078	+3.176	.002	.002	1	4
BLOOD_Leukemia	FER1L6 →	+2.177	+2.774	.004	.004	1	4
LARGE_INTESTINE	AGT →	+2.736	+3.208	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,898 associations by consensus.

RPTOR by PTBP1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →