PTAFR

Across TCGA pan-cancer cohorts, PTAFR mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PTAFR’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PTAFR mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PTAFR is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where PTAFR tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTAFR mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	+0.464	<.001	6	view →
HNSC	Male	All	+0.254	.006	5	view →
LSCC	Male	All	−0.305	<.001	4	view →
PDAC	Male	II,III,IV	−0.802	.010	1	view →
LUAD	Female	All	−0.263	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PTAFR–CCRCC

Open the CCRCC breakdown →