PSTPIP2

Across TCGA patient cohorts, PSTPIP2 mutation is significantly associated with the RNA expression of many other genes, with 1,233 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSTPIP2-associated genes across cancer lineages are MIR3648-2, RNU6-751P, and USP9YP10. Each is linked with PSTPIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSTPIP2-to-partner and partner-to-PSTPIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3648-2 grouped by PSTPIP2-low versus PSTPIP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSTPIP2→partner) and Y-score (partner→PSTPIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3648-2 →	+0.175	+4.225	<.001	.007	3	2
UCEC	RNU6-751P →	+0.144	+4.151	<.001	.006	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1
LGG	RNU1-48P →	+0.304	+7.977	<.001	.007	3	1
COAD	RNU1-35P →	+0.461	+3.797	<.001	.003	3	1
COAD	RNU6-968P →	+0.379	+3.868	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,233 associations by consensus.

MIR3648-2 by PSTPIP2 expression — COAD

Explore this box plot interactively →