PSTK

Across TCGA patient cohorts, PSTK mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSTK-associated genes across cancer lineages are Chk2, Rad50, and MEK1. Each is linked with PSTK in more than 1 cancer types. Because this analysis shows association rather than direction, both PSTK-to-partner and partner-to-PSTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2 grouped by PSTK-low versus PSTK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSTK→partner) and Y-score (partner→PSTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2 →	-0.303	-3.169	.018	.020	3	1
UCEC	Rad50 →	-0.263	-3.169	.048	.020	2	1
UCEC	MEK1 →	+0.424	+3.169	.034	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Chk2 by PSTK expression — UCEC

Explore this box plot interactively →