PSTK

Across TCGA cell cohorts, PSTK RNA expression is significantly associated with the go_rna of many other GO terms, with 2,890 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PSTK-associated GO terms across cancer lineages are Positive regulation of DNA repair, Nucleotide-excision repair, and Mitochondrial DNA replication. Each is linked with PSTK in more than 9 cancer types. Because this analysis shows association rather than direction, both PSTK-to-partner and partner-to-PSTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by PSTK-low versus PSTK-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSTK→partner) and Y-score (partner→PSTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of DNA repair →	+0.044	+0.442	.001	.007	3	10
SKIN	Nucleotide-excision repair →	+0.043	+0.638	<.001	<.001	3	9
PANCREAS	Mitochondrial DNA replication →	+0.087	+0.830	.004	<.001	3	8
BLOOD_Leukemia	T cell mediated immunity →	-0.097	-0.546	<.001	.003	3	8
BLOOD_Leukemia	Protein localization to chromosome →	+0.079	+0.588	<.001	<.001	3	8
SKIN	snRNA metabolic process →	+0.043	+0.625	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,890 associations by consensus.

Positive regulation of DNA repair by PSTK expression — SOFT_TISSUE

Explore this box plot interactively →