PSTK

Across TCGA cell cohorts, PSTK mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSTK-associated genes across cancer lineages are TOPAZ1, TXNDC8, and USP14. Each is linked with PSTK in more than 1 cancer types. Because this analysis shows association rather than direction, both PSTK-to-partner and partner-to-PSTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOPAZ1 grouped by PSTK-low versus PSTK-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSTK→partner) and Y-score (partner→PSTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TOPAZ1 →	+0.013	+5.169	<.001	.005	3	1
BREAST	TXNDC8 →	+0.006	+5.781	<.001	.001	3	1
LARGE_INTESTINE	USP14 →	+0.738	+3.087	.002	.006	3	1
LARGE_INTESTINE	MYH3 →	+0.766	+3.064	<.001	.009	3	1
LARGE_INTESTINE	PPP1R8 →	+0.584	+3.125	<.001	.008	3	1
LARGE_INTESTINE	USP26 →	+0.038	+2.836	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

TOPAZ1 by PSTK expression — BREAST

Explore this box plot interactively →