PSPN

Across TCGA patient cohorts, PSPN RNA expression is significantly associated with the mutation status of many other genes, with 11,741 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSPN-associated genes across cancer lineages are TP53, MUC17, and PIK3CA. Each is linked with PSPN in more than 3 cancer types. Because this analysis shows association rather than direction, both PSPN-to-partner and partner-to-PSPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by PSPN-low versus PSPN-high in BRCA.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSPN→partner) and Y-score (partner→PSPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TP53 →	-1.579	-0.381	<.001	<.001	3	4
STAD	MUC17 →	+2.840	+0.331	.001	<.001	3	4
BRCA	PIK3CA →	+0.566	+0.113	<.001	.001	3	4
HNSC	DOCK2 →	+3.216	+0.738	.009	<.001	3	4
UCEC	CUL7 →	+2.113	+0.316	<.001	<.001	3	4
UCEC	KIF1B →	+2.476	+0.429	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,741 associations by consensus.

TP53 by PSPN expression — BRCA

Explore this box plot interactively →