PSPN

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PSPN protein abundance is significantly associated with the RNA expression of many other genes, with 3,966 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PSPN-associated genes across cancer lineages are MCM8, PIMREG, and SGO1. Each is linked with PSPN in more than 1 cancer types. Because this analysis shows association rather than direction, both PSPN-to-partner and partner-to-PSPN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PSPN versus MCM8 in UCEC, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSPN→partner) and Y-score (partner→PSPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMCM8 →-0.728-0.970<.001<.00132
GBMPIMREG →-1.222-0.644.001<.00132
UCECSGO1 →-1.029-0.818.001<.00132
UCECPOLR3F →-0.359-0.746<.001<.00132
UCECTROAP →-1.082-0.811.003.00132
GBMFAM117B →-0.683-0.633.005.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,966 associations by consensus.

PSPN vs MCM8 — UCEC

Per-sample scatter of PSPN vs MCM8 in UCEC (Pearson r = -0.48).

Explore this scatter interactively →

Exploration