PSPH

Across TCGA pan-cancer cohorts, PSPH mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PSPH data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PSPH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PSPH expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where PSPH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	1.000	0.790	.008	27	view →
LUAD	OS	Tertile	All	0.528	1.000	<.001	17	view →
CCRCC	OS	Median	II,III,IV	0.857	0.614	.010	9	view →
PDAC	OS	Median	II,III,IV	0.242	0.503	.003	4	view →
HNSC	DFS	Median	IV	0.585	0.783	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PSPH–LSCC (DFS)

Open the LSCC breakdown →