PSPH

Across TCGA pan-cancer cohorts, PSPH RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PSPH’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PSPH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSPH is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where PSPH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSPH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+1.600	<.001	11	view →
HNSC	All	III,IV	+1.190	<.001	11	view →
LIHC	Female	II,III,IV	+1.897	<.001	9	view →
BLCA	All	All	+1.089	<.001	9	view →
KICH	Female	II,III,IV	−1.854	<.001	8	view →
LUAD	All	III,IV	+1.288	<.001	8	view →
THCA	Male	III,IV	−0.978	<.001	8	view →
KIRC	All	IV	+0.555	.003	8	view →
KIRP	All	II,III,IV	+0.725	<.001	7	view →
LUSC	Male	All	+1.682	<.001	6	view →
STAD	Male	II,III,IV	+1.060	<.001	6	view →
BRCA	All	II,III,IV	+0.738	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PSPH–COAD

Open the COAD breakdown →