PSPH

Across TCGA patient cohorts, PSPH protein abundance is significantly associated with the RNA expression of many other genes, with 10,355 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PSPH-associated genes across cancer lineages are GARS1, PSAT1, and CCT6A. Each is linked with PSPH in more than 7 cancer types. Because this analysis shows association rather than direction, both PSPH-to-partner and partner-to-PSPH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PSPH versus GARS1 in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSPH→partner) and Y-score (partner→PSPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GARS1 →	+0.591	+0.410	<.001	<.001	3	8
BRCA	PSAT1 →	+1.471	+0.286	<.001	.001	3	7
GBM	CCT6A →	+1.382	+1.126	<.001	<.001	3	7
BRCA	PHGDH →	+1.268	+0.377	<.001	<.001	3	6
GBM	ZNF713 →	+1.399	+1.060	<.001	<.001	3	5
GBM	MRPS17 →	+1.339	+1.237	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,355 associations by consensus.

PSPH vs GARS1 — BRCA

Explore this scatter interactively →