PSMG3-AS1

Across TCGA pan-cancer cohorts, PSMG3-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PSMG3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PSMG3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PSMG3-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where PSMG3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMG3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.057	<.001	12	view →
KICH	Male	All	−1.863	<.001	10	view →
LUSC	Male	II,III,IV	−1.219	<.001	8	view →
THCA	Male	III,IV	−1.111	<.001	8	view →
LIHC	All	III,IV	+0.900	<.001	8	view →
COAD	Female	II,III,IV	−0.736	<.001	8	view →
UCEC	All	II,III,IV	−1.432	<.001	6	view →
BRCA	All	II,III,IV	−0.617	<.001	6	view →
HNSC	Male	All	−0.358	.018	4	view →
CHOL	All	All	+1.158	<.001	3	view →
BLCA	Male	IV	−0.952	<.001	2	view →
KIRP	All	III,IV	−0.593	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PSMG3-AS1–KIRC

Open the KIRC breakdown →