PSME4

Across TCGA patient cohorts, PSME4 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,564 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PSME4-associated proteins across cancer lineages are SPAST, RRM2, and MCM2_S27. Each is linked with PSME4 in more than 6 cancer types. Because this analysis shows association rather than direction, both PSME4-to-partner and partner-to-PSME4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PSME4 versus SPAST in LSCC, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME4→partner) and Y-score (partner→PSME4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPAST →	+0.502	+0.495	<.001	<.001	3	7
UCEC	RRM2 →	+0.554	+0.412	<.001	<.001	3	6
BRCA	MCM2_S27 →	+0.514	+0.406	.006	.003	3	6
LSCC	MCM5 →	+0.512	+0.401	<.001	<.001	3	6
UCEC	SMC4 →	+0.444	+0.341	<.001	.002	3	6
LSCC	HAT1 →	+0.363	+0.342	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,564 associations by consensus.

PSME4 vs SPAST — LSCC

Explore this scatter interactively →