PSMD7

Across TCGA patient cohorts, PSMD7 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD7-associated genes across cancer lineages are eIF4E, Ku80, and MEK1. Each is linked with PSMD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD7-to-partner and partner-to-PSMD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PSMD7-low versus PSMD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD7→partner) and Y-score (partner→PSMD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.215	+3.584	.013	.002	3	1
UCEC	Ku80 →	+0.277	+1.820	.004	.016	3	1
UCEC	MEK1 →	+0.441	+2.115	.003	.017	3	1
UCEC	MSH2 →	-0.344	-2.321	<.001	.006	3	1
UCEC	NF2 →	+0.281	+1.807	.001	.027	3	1
UCEC	Notch1 →	+0.198	+2.335	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by PSMD7 expression — UCEC

Explore this box plot interactively →