PSMD7

Across TCGA pan-cancer cohorts, PSMD7 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PSMD7 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PSMD7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMD7 expression acts as an unfavorable survival marker, although some lineages such as COAD and SCLC show a favorable association.

HNSC, ACC, and BLCA are the cancer types where PSMD7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.221	0.437	<.001	67	view →
ACC	OS	Median	All	0.769	0.970	<.001	61	view →
BLCA	DFS	Tertile	All	0.452	0.612	.001	50	view →
BRCA	OS	Quartile	II,III,IV	0.881	0.955	<.001	39	view →
LIHC	DFS	Quartile	All	0.291	0.534	<.001	38	view →
PAAD	DFS	Tertile	All	0.204	0.440	.002	35	view →
LUAD	DFS	Median	All	0.607	0.719	.001	32	view →
KIRP	DFS	Quartile	All	0.863	0.968	.004	31	view →
MESO	OS	Quartile	All	0.207	0.509	.005	31	view →
UVM	DFS	Tertile	III,IV	0.177	1.000	.007	27	view →
COAD	OS	Median	IV	0.772	0.516	.004	23	view →
LAML	DFS	Tertile	All	0.271	0.480	.002	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PSMD7–HNSC (DFS)

Open the HNSC breakdown →