PSMD6

Across TCGA patient cohorts, PSMD6 mutation is significantly associated with the RNA expression of many other genes, with 1,451 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD6-associated genes across cancer lineages are RNY4P27, RNA5SP86, and MTATP6P21. Each is linked with PSMD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD6-to-partner and partner-to-PSMD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P27 grouped by PSMD6-low versus PSMD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD6→partner) and Y-score (partner→PSMD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNY4P27 →	+0.160	+3.132	<.001	.001	3	2
UCEC	RNA5SP86 →	+0.515	+2.373	<.001	.004	3	2
UCEC	MTATP6P21 →	+0.236	+1.967	<.001	.002	3	2
UCEC	DPY19L4P2 →	+0.111	+2.239	<.001	<.001	3	2
UCEC	RN7SL191P →	+0.170	+2.496	<.001	.001	3	2
UCEC	RN7SL318P →	+0.252	+2.053	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,451 associations by consensus.

RNY4P27 by PSMD6 expression — UCEC

Explore this box plot interactively →