PSMD3

Across TCGA patient cohorts, PSMD3 mutation is significantly associated with the RNA expression of many other genes, with 1,062 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD3-associated genes across cancer lineages are RNU6-1093P, MIR758, and MTND4P6. Each is linked with PSMD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSMD3-to-partner and partner-to-PSMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1093P grouped by PSMD3-low versus PSMD3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD3→partner) and Y-score (partner→PSMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1093P →	+0.306	+4.625	<.001	.008	3	3
SKCM	MIR758 →	+0.182	+5.906	<.001	<.001	3	2
COAD	MTND4P6 →	+0.711	+5.283	<.001	.006	3	2
LUAD	RNA5SP228 →	+0.290	+7.924	<.001	<.001	3	2
COAD	RNU6-455P →	+0.980	+5.516	<.001	.004	3	2
UCEC	TRAJ21 →	+0.550	+2.651	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,062 associations by consensus.

RNU6-1093P by PSMD3 expression — LUSC

Explore this box plot interactively →