PSMD3

Across TCGA patient cohorts, PSMD3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD3-associated genes across cancer lineages are MSH2, Fibronectin, and MEK1_p_S217_S221. Each is linked with PSMD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD3-to-partner and partner-to-PSMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by PSMD3-low versus PSMD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD3→partner) and Y-score (partner→PSMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.274	-3.433	.005	.005	3	2
UCEC	Fibronectin →	-0.301	-1.990	.031	.030	3	1
UCEC	MEK1_p_S217_S221 →	+0.258	+2.999	.026	.035	3	1
UCEC	p90 RSK →	+0.239	+3.169	.003	.018	3	1
UCEC	Rictor_pT1135 →	-0.097	-2.999	.026	.035	3	1
UCEC	S6_pS240_S244 →	+0.416	+1.700	.015	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MSH2 by PSMD3 expression — UCEC

Explore this box plot interactively →