PSMD3

Across TCGA cell cohorts, PSMD3 mutation is significantly associated with the mutation status of many other genes, with 1,920 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PSMD3-associated genes across cancer lineages are BRPF1, RNF31, and EPB41L4B. Each is linked with PSMD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSMD3-to-partner and partner-to-PSMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRPF1 grouped by PSMD3-low versus PSMD3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD3→partner) and Y-score (partner→PSMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BRPF1 →	+4.239	+5.053	.007	.007	1	3
BLOOD_Leukemia	RNF31 →	+4.050	+4.260	<.001	<.001	1	2
BLOOD_Leukemia	EPB41L4B →	+4.050	+4.820	<.001	<.001	1	2
BLOOD_Leukemia	TRAF3IP3 →	+3.635	+3.635	.003	.003	1	2
BLOOD_Leukemia	MZF1 →	+3.313	+3.430	.005	.005	1	2
BLOOD_Leukemia	CDHR5 →	+2.465	+3.156	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,920 associations by consensus.

BRPF1 by PSMD3 expression — SKIN

Explore this box plot interactively →