PSMC5

Across TCGA patient cohorts, PSMC5 mutation is significantly associated with the RNA expression of many other genes, with 1,383 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC5-associated genes across cancer lineages are MED28P4, RNU6-178P, and PABPC1L2B-AS1. Each is linked with PSMC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC5-to-partner and partner-to-PSMC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED28P4 grouped by PSMC5-low versus PSMC5-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC5→partner) and Y-score (partner→PSMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MED28P4 →	+0.394	+5.039	<.001	.008	3	2
COAD	RNU6-178P →	+0.864	+4.437	<.001	.002	3	2
COAD	PABPC1L2B-AS1 →	+0.031	+6.149	<.001	<.001	3	2
READ	ACTRT2 →	+0.102	+6.257	<.001	.001	3	1
READ	OLIG3 →	+0.314	+5.421	<.001	.005	3	1
LUSC	TTTY20 →	+1.361	+5.706	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,383 associations by consensus.

MED28P4 by PSMC5 expression — READ

Explore this box plot interactively →