PSMC3

Across TCGA patient cohorts, PSMC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,847 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PSMC3-associated proteins across cancer lineages are SMC4, MCM4, and MCM6. Each is linked with PSMC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both PSMC3-to-partner and partner-to-PSMC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PSMC3 versus SMC4 in GBM, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC3→partner) and Y-score (partner→PSMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC4 →	+0.726	+0.420	<.001	<.001	3	7
GBM	MCM4 →	+0.717	+0.338	<.001	.001	3	7
GBM	MCM6 →	+0.790	+0.350	<.001	.001	3	7
LUAD	NCAPD2 →	+0.499	+0.280	<.001	.004	3	6
BRCA	NCAPH →	+0.557	+0.432	.001	.008	3	6
LUAD	NDC80 →	+0.515	+0.330	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,847 associations by consensus.

PSMC3 vs SMC4 — GBM

Explore this scatter interactively →