PSMC1P9

Across TCGA pan-cancer cohorts, PSMC1P9 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PSMC1P9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PSMC1P9 RNA is repressed in tumor relative to normal tissue. In most cancer types PSMC1P9 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BRCA are the cancer types where PSMC1P9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMC1P9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.127	<.001	11	view →
KICH	Male	All	−0.146	.002	7	view →
BRCA	Female	All	−0.304	<.001	6	view →
ESCA	All	All	−0.807	.007	2	view →
KIRP	All	All	−0.122	<.001	2	view →
LUSC	All	All	+0.063	.005	2	view →
PRAD	All	All	−0.062	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PSMC1P9–KIRC

Open the KIRC breakdown →