PSMB6

Across TCGA pan-cancer cohorts, PSMB6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PSMB6 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PSMB6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PSMB6 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where PSMB6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.890	0.475	<.001	27	view →
PDAC	DFS	Quartile	III,IV	0.438	0.925	.001	19	view →
HNSC	DFS	Tertile	All	0.991	0.906	.047	3	view →
LUAD	DFS	Tertile	III,IV	0.419	0.854	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PSMB6–LSCC (DFS)

Open the LSCC breakdown →