PSMB6

Across TCGA pan-cancer cohorts, PSMB6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PSMB6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PSMB6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSMB6 is over-expressed in tumor, although a few such as KICH and READ show the opposite, repressed pattern.

HNSC, KICH, and COAD are the cancer types where PSMB6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMB6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.436	<.001	10	view →
KICH	Female	II,III,IV	−1.512	<.001	8	view →
COAD	Female	II,III,IV	+0.429	.002	7	view →
LUSC	Male	II,III,IV	+0.527	<.001	6	view →
LIHC	All	II,III,IV	+0.519	<.001	6	view →
BLCA	All	All	+0.470	.003	6	view →
UCEC	All	III,IV	+0.628	.042	4	view →
KIRP	All	II,III,IV	+0.363	.012	4	view →
KIRC	All	IV	+0.333	.009	4	view →
CHOL	Male	All	+1.424	<.001	3	view →
ESCA	All	All	+0.803	.006	2	view →
STAD	All	II,III,IV	+0.312	.047	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PSMB6–HNSC

Open the HNSC breakdown →