PSMB6

Across TCGA patient cohorts, PSMB6 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB6-associated genes across cancer lineages are SCD and FOXO3a. Each is linked with PSMB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB6-to-partner and partner-to-PSMB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCD grouped by PSMB6-low versus PSMB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB6→partner) and Y-score (partner→PSMB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCD →	+0.149	+2.820	.027	.036	3	1
UCEC	FOXO3a →	+0.134	+2.820	.031	.036	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

SCD by PSMB6 expression — UCEC

Explore this box plot interactively →