PSMB5

Across TCGA pan-cancer cohorts, PSMB5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PSMB5 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PSMB5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PSMB5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where PSMB5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.922	0.490	<.001	26	view →
PDAC	DFS	Tertile	III,IV	0.285	0.979	<.001	15	view →
LUAD	OS	Median	II,III,IV	0.437	0.804	.015	12	view →
HNSC	OS	Median	All	1.000	0.959	.023	8	view →
GBM	DFS	Quartile	All	0.748	0.605	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PSMB5–LSCC (DFS)

Open the LSCC breakdown →