PSMB5

Across TCGA pan-cancer cohorts, PSMB5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PSMB5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PSMB5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSMB5 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, HNSC, and BLCA are the cancer types where PSMB5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMB5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+1.056	<.001	12	view →
HNSC	Male	IV	+0.933	<.001	12	view →
BLCA	Male	III,IV	+0.859	<.001	11	view →
LIHC	Female	II,III,IV	+1.369	<.001	9	view →
LUAD	All	III,IV	+0.742	<.001	9	view →
LUSC	Male	II,III,IV	+1.004	<.001	8	view →
STAD	Male	II,III,IV	+0.732	<.001	7	view →
UCEC	All	II,III,IV	+0.912	<.001	6	view →
KICH	Female	II,III,IV	−0.861	<.001	6	view →
BRCA	All	III,IV	+0.676	<.001	6	view →
CHOL	Male	All	+1.865	<.001	5	view →
KIRP	All	II,III,IV	+0.415	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PSMB5–COAD

Open the COAD breakdown →