PSMB5

Across TCGA patient cohorts, PSMB5 mutation is significantly associated with the RNA expression of many other genes, with 1,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB5-associated genes across cancer lineages are LINC01943, ABALON, and LAMTOR1. Each is linked with PSMB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB5-to-partner and partner-to-PSMB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01943 grouped by PSMB5-low versus PSMB5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB5→partner) and Y-score (partner→PSMB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01943 →	+0.477	+3.364	.002	.004	3	1
UCEC	ABALON →	+0.524	+3.212	.001	.009	3	1
UCEC	LAMTOR1 →	+0.416	+2.917	.002	.001	3	1
UCEC	TKFC →	+0.461	+2.724	.003	.003	3	1
UCEC	CHEK1 →	+0.726	+2.243	.001	.006	3	1
UCEC	CCT5 →	+0.588	+3.224	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,130 associations by consensus.

LINC01943 by PSMB5 expression — UCEC

Explore this box plot interactively →