PSMB5

Across TCGA patient cohorts, PSMB5 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB5-associated genes across cancer lineages are eEF2, EGFR_pY1068, and GAPDH. Each is linked with PSMB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB5-to-partner and partner-to-PSMB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PSMB5-low versus PSMB5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB5→partner) and Y-score (partner→PSMB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.497	+3.321	.001	.009	3	1
UCEC	EGFR_pY1068 →	-0.334	-2.807	.002	.003	3	1
UCEC	GAPDH →	+0.635	+3.459	.006	.005	3	1
UCEC	GATA6 →	-0.172	-2.693	.013	.006	3	1
UCEC	mTOR_pS2448 →	-0.230	-3.565	<.001	.002	3	1
UCEC	p21 →	+0.183	+3.013	.029	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eEF2 by PSMB5 expression — UCEC

Explore this box plot interactively →