PSMB5

Across TCGA cell cohorts, PSMB5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,906 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PSMB5-associated GO terms across cancer lineages are Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Regulation of translational fidelity, and Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with PSMB5 in more than 14 cancer types. Because this analysis shows association rather than direction, both PSMB5-to-partner and partner-to-PSMB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by PSMB5-low versus PSMB5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB5→partner) and Y-score (partner→PSMB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.132	+1.099	<.001	<.001	3	15
BONE	Regulation of translational fidelity →	+0.114	+0.679	.001	.002	3	13
OVARY	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.115	+0.676	<.001	<.001	3	13
BONE	Mitochondrial RNA 5'-end processing →	+0.132	+0.655	.003	.002	3	13
OVARY	rRNA 5'-end processing →	+0.115	+0.676	<.001	<.001	3	13
PANCREAS	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.113	+0.681	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,906 associations by consensus.

Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by PSMB5 expression — UPPER_AERODIGESTIVE_TRACT

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