PSMB4

Across TCGA cell cohorts, PSMB4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSMB4-associated genes across cancer lineages are C14orf180, TAAR6, and SCGB3A2. Each is linked with PSMB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB4-to-partner and partner-to-PSMB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf180 grouped by PSMB4-low versus PSMB4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB4→partner) and Y-score (partner→PSMB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C14orf180 →	+0.167	+3.477	<.001	.001	3	2
BLOOD_Leukemia	TAAR6 →	+0.018	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.103	+4.922	.002	.009	3	1
LARGE_INTESTINE	ASPA →	+0.502	+2.874	<.001	.008	3	1
LARGE_INTESTINE	TAAR5 →	+0.010	+3.700	<.001	.009	3	1
LARGE_INTESTINE	AGRP →	+0.120	+2.994	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

C14orf180 by PSMB4 expression — LARGE_INTESTINE

Explore this box plot interactively →