PSMB2

Across TCGA patient cohorts, PSMB2 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB2-associated genes across cancer lineages are GMCL1P2, MIR6803, and CSNK1A1L. Each is linked with PSMB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB2-to-partner and partner-to-PSMB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMCL1P2 grouped by PSMB2-low versus PSMB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB2→partner) and Y-score (partner→PSMB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GMCL1P2 →	+0.264	+3.307	.002	.001	3	1
UCEC	MIR6803 →	+0.307	+5.671	<.001	<.001	3	1
UCEC	CSNK1A1L →	+0.107	+3.651	.001	.005	3	1
UCEC	SSXP4 →	+0.069	+4.662	.001	.003	3	1
UCEC	SPATA31D4 →	+0.010	+4.123	<.001	.001	3	1
UCEC	RNU6-831P →	+0.314	+4.123	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

GMCL1P2 by PSMB2 expression — UCEC

Explore this box plot interactively →